| Singles competition |
| 1. #25 Hunter Bajoit (SWU) def. Ryan Olps (SEWANEE) 6-2, 6-3 |
| 2. Noah Holsclaw (SEWANEE) def. Vesko Lekovic (SWU) 7-6 (7-3), 6-2 |
| 3. Matt Barnett (SEWANEE) def. Anton Borovik (SWU) 7-6 (7-0), 1-6, 7-6 (12-10) |
| 4. Quinn Wicklund (SEWANEE) def. Oscar Roy (SWU) 6-1, 6-3 |
| 5. Steven Tibbetts (SWU) def. Gil Weston (SEWANEE) 6-0, 7-6 (10-8) |
| 6. Talman Ramsey (SEWANEE) def. Carlos Esteban (SWU) 6-3, 6-3 |
| Doubles competition |
| 1. #20 Hunter Bajoit/Hemanshu Rambojun (SWU) def. Ryan Olps/Noah Holsclaw (SEWANEE) 8-2 |
| 2. Quinn Wicklund/Mark Motlow (SEWANEE) def. Jared Burton/Vesko Lekovic (SWU) 8-4 |
| 3. Liam Baer/Hugh Graham (SEWANEE) def. Oscar Roy/Steven Tibbetts (SWU) 8-6 |
| Match Notes |
| Sewanee 1-3 |
| Southwestern 1-4 |
| Southwestern finished the 2021 season ranked 10th in final ITA poll. |
| Sewanee finished the 2021 season ranked 22nd in final ITA poll |