| Singles competition |
| 1. Taylor Garcia (WLU) def. #46 Brooke Despriet (SEW) 1-6, 6-3, 7-6 (7-5) |
| 2. Alice Hall (SEW) def. #11 Gabi Moss (WLU) 6-2, 3-6, 1-0 (10-1) |
| 3. Emma Smith (SEW) def. Izzy Koziol (WLU) 2-6, 6-3, 6-3 |
| 4. Ansley Carpenter (SEW) def. Marta Mikos (WLU) 7-5, 7-5 |
| 5. Becket Waters (WLU) def. Sarah Livingston (SEW) 6-4, 3-6, 1-0 (11-9) |
| 6. Natalia Nassar (SEW) def. Kaitlyn Chalker (WLU) 6-1, 6-4 |
| Doubles competition |
| 1. Brooke Despriet/Alice Hall (SEW) def. Taylor Garcia/Margaret Carlton (WLU) 8-5 |
| 2. Natalia Nassar/Ansley Carpenter (SEW) def. Becket Waters/Gabi Moss (WLU) 8-3 |
| 3. Emma Smith/Caroline Adams (SEW) def. Marta Mikos/Kaitlyn Chalker (WLU) 8-2 |
| Match Notes |
| University of the South 3-0 |
| Washington and Lee University 3-1 |
| Washington and Lee finished 2021 season ranked 9th in final ITA poll. |
| Sewanee finished 2021 season ranked 6th in final ITA poll. |